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view, common among Stoics, that each individual had some unique property, 
or essence, that remained unchanged throughout the life of the individual, and 
by which, despite other radical changes, the individual could be identified.
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Such ideas, which might have led to what we think of as a modern, relational 
view of personal identity, were overshadowed in the Roman period by the 
ascendancy  of  Neoplatonism,  which  through  the  influence  primarily  of 
Augustine provided the framework for Christian theology from the fourth to 
the thirteenth centuries. 
Related to these earlier Greek materialistic atomistic philosophies, but with a 
more practical focus, were the medical materialists. The earliest Greek physi-
cians, whose medical works were collectively attributed to Hippocrates, worked 
under the assumption that both mental (
psyche ) and physical (
soma ) illnesses had
their  basis  in  the  physical  constitution  of  humans ( physis ).  For  instance, 
Hippocrates’
On the Sacred Disease
begins: “It [epilepsy] appears to me to be nowise 
more divine nor more sacred than other diseases, but has a natural cause from 
which it originates like other affections.” He goes on to describe the similarity of 
this “sacred” disease with other maladies involving insanity, after which he 
explains why some forms of mental illness are said to be sacred: “They who first 
referred this malady to the gods appear to me to have been just such persons as 
the conjurors, purificators, mountebanks, and charlatans now are, who give 
themselves out for being excessively religious, and as knowing more than other 
people.” These people, he continued, use “divinity as a pretext and screen” for 
their own ignorance. Hippocrates’ own view was that “the brain,” which is “the 
primary seat of sense and of the spirits” and  “perceives whatever occurs in 
the body,” is “the cause of [these] afflictions.” Some of these disturbances affect 
the brain itself and lead to mental illness. Thus, in his view, the way to treat this 
illness is to treat the brain.
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Subsequently anatomical investigations by Herophilus and Erasistratus 
(c. 330-250 b.c.e.) established the role that nerves play in connecting the brain to 
the rest of the body. This discovery, apparently, had a great impact on Epicurean 
and Stoic philosophers of the time, including physicians, since it provided a clear 
means of explaining in a physical way how mind and body might interact. If the 
brain were the seat of the mind and could communicate through the nerves to 
the rest of the body, the activities of the body could be known. The body, then, 
would not require an immaterial mind that operates, in some unknowable 
fashion, on all parts of the body. Instead, the mind itself could be some kind of 
“spiritual matter” (pneuma) of a thin and rapidly moving sort. It could have the 
brain as its center but through the nerves grow tendrils to the rest of the body 
and in this way both feel and control distant parts of the body.
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